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(2S,5R,6R)-6-amino-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid

6-Aminopenicillanic acid

CAS: 551-16-6

Molecular Formula: C8H12N2O3S

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(2S,5R,6R)-6-amino-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid - Names and Identifiers

Name 6-Aminopenicillanic acid
Synonyms 6apa
6-APA
aminopenicillanic acid
6-AMINOPENICILLANIC ACID
6-Aminopenicillanic acid
6-AMINO PENICILLINIC ACID
(+)-6-AMINOPENICILLANIC ACID
6-AMINO-2,2-DIMETHYL-5-OXOPERHYDROAZETO[2,1-B][1,3]THIAZOLE-3-CARBOXYLIC ACID
6-AMINO-3,3-DIMETHYL-7-OXO-4-THIA-1-AZABICYCLO[3.2.0]HEPTANE-2-CARBOXYLIC ACID
7-AMINO-3,3-DIMETHYL-6-OXO-2-THIA-5-AZABICYCLO[3.2.0]HEPTANE-4-CARBOXYLIC ACID
6-Amino-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
(2S,5R,6R)-6-amino-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
(25,5R,6R)-6-AMINO-3,3-DIMETHYL-7-OXO-4-THIA-1-AZABICYCLO[3.2.0]HEPTANE-2-CARBOXYLIC ACID
4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-amino-3,3-dimethyl-7-oxo-, [2S-(2alpha,5alpha,6beta)]-
CAS 551-16-6
EINECS 208-993-4
InChI InChI=1/C8H12N2O3S/c1-8(2)4(7(12)13)10-5(11)3(9)6(10)14-8/h3-4,6H,9H2,1-2H3,(H,12,13)/t3-,4+,6-/m1/s1
InChIKey NGHVIOIJCVXTGV-SDKNWNMFSA-N

(2S,5R,6R)-6-amino-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid - Physico-chemical Properties

Molecular FormulaC8H12N2O3S
Molar Mass216.26
Density1.3418 (rough estimate)
Melting Point198-200°C (dec.)(lit.)
Boling Point460.2±45.0 °C(Predicted)
Specific Rotation(α)276.3 º (c=1.2, 0.1N HCl 22 ºC)
Flash Point232.1°C
Water SolubilitySoluble in water and hydrochoric acid.
Solubility Slightly soluble in water, insoluble in butyl acetate, ethanol or acetone.
Vapor Presure9.54E-10mmHg at 25°C
AppearanceWhite or yellowish crystalline powder
ColorWhite to cream
Merck14,458
BRN15080
pKapKa 2.3 (Uncertain)
PH3.4 (100g/l, H2O)
Storage Condition2-8°C
Refractive Index1.6300 (estimate)
MDLMFCD00005176
Physical and Chemical PropertiesWhite crystals. Melting point 208-209 ℃, slightly soluble in water, insoluble in general organic solvents. Antibacterial ability is very small, through the chemical method, the introduction of different side chains, and obtain a variety of different efficacy of penicillin.
UseUsed as a pharmaceutical Intermediate

(2S,5R,6R)-6-amino-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid - Risk and Safety

Hazard SymbolsXn - Harmful
Harmful
Risk Codes42/43 - May cause sensitization by inhalation and skin contact.
Safety DescriptionS22 - Do not breathe dust.
S36/37 - Wear suitable protective clothing and gloves.
S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S37 - Wear suitable gloves.
S24 - Avoid contact with skin.
S36 - Wear suitable protective clothing.
WGK Germany2
RTECSXH8225000
FLUKA BRAND F CODES10
TSCAYes
HS Code29349990

(2S,5R,6R)-6-amino-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid - Upstream Downstream Industry

Raw MaterialsBenzylpenicillin potassium
Penicillin G Sodium
Downstream ProductsAmoxicillin

(2S,5R,6R)-6-amino-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid - Introduction

In case of alkali decomposition, it is more stable to acid.
Last Update：2022-10-16 17:26:15
(2S,5R,6R)-6-amino-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
Supplier List
Hubei YoungXin Pharmaceutical Tech Co.,Ltd.
Multiple SpecificationsSpot supply
Product Name: Amoxicillin Impurity 1（Amoxicillin EP Impurity A） Visit Supplier Webpage Request for quotation
CAS: 551-16-6
Tel: 0714-3999186
Email: 2853786052@qq.com
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Hefei TNJ Chemical Industry Co.,Ltd.
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CAS: 551-16-6
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Shanghai Yuanye Bio-Technology Co., Ltd.
Multiple SpecificationsSpot supply
Product Name: 6-APA Visit Supplier Webpage Request for quotation
CAS: 551-16-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
Wechat: 18301782025
Hubei YoungXin Pharmaceutical Tech Co.,Ltd.
Multiple SpecificationsSpot supply
Product Name: Amoxicillin Impurity 1（Amoxicillin EP Impurity A） Visit Supplier Webpage Request for quotation
CAS: 551-16-6
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052 Click to send a QQ message
Wechat: 15671228036
Hefei TNJ Chemical Industry Co.,Ltd.
Product Name: 6-Aminopenicillanic acid Request for quotation
CAS: 551-16-6
Tel: 0086-551-65418684
Email: sales@tnjchem.com
　　　　 info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840 Click to send a QQ message
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Shanghai Yuanye Bio-Technology Co., Ltd.
Multiple SpecificationsSpot supply
Product Name: 6-APA Visit Supplier Webpage Request for quotation
CAS: 551-16-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
Wechat: 18301782025
View History
(2S,5R,6R)-6-amino-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
Raw Materials for (2S,5R,6R)-6-amino-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
Benzylpenicillin potassium
Penicillin G Sodium
Downstream Products for (2S,5R,6R)-6-amino-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
Amoxicillin
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